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A ruptured recurrent small bowel gastrointestinal stromal tumour causing hemoperitoneum
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《医学前沿(英文)》 2015年 第9卷 第1期 页码 108-111 doi: 10.1007/s11684-014-0344-0
Hemoperitoneum is a rare and potentially life-threatening complication of GIST. We reported a 54-year-old man who developed disseminated intra-abdominal recurrence from a previously resected gastrointestinal stromal tumour (GIST) of the small bowel, and the patient presented with hemoperitoneum. Emergent debulking surgery was performed. A high dose imatinib was prescribed. Despite the presence of residual disease, the patient was well clinically 8 months after the operation. Even though, there is no evidence to support the routine use of debulking surgery in the management of GIST. In our patient, disease progression after second line targeted therapy and the absence of alternative treatment options for spontaneous rupture and hemoperitoneum prompted us to treat the patient aggressively. Resection of the ruptured GIST was carried out for control of bleeding and to prevent recurrent bleeding in this patient with good surgical risks. During the treatment decision-making, the patient’s general condition, the risk of surgery and the extent of dissemination were taken into consideration. In this patient who presented with spontaneous rupture of a small intestinal GIST, the novel use of targeted therapy and aggressive surgical treatment produced reasonably good survival outcome.
关键词: gastrointestinal stromal tumour hemoperitoneum small bowel GIST small bowel neoplasm imatinib
Potential indicators predict progress after surgical resection of gastrointestinal stromal tumors
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《医学前沿(英文)》 2012年 第6卷 第3期 页码 317-321 doi: 10.1007/s11684-012-0203-9
In order to find out the potential indicators predicting prognosis of malignant gastrointestinal stromal tumors (GISTs) after surgical resection, we collected clinical records of 80 patients with malignant GISTs. Tumor location, size, mitotic index, necrosis were compared with the prognosis of malignant GISTs by Kaplan-Meier method and log-rank test. After a median follow-up of 844 days (52–2 145), we found that as National Institutes of Health suggested, tumors with intermediate risk had more favorable prognosis than that with high risk. Their 3-year survival rate were 65.3% and 41.3%, respectively (P<0.001). Moreover, tumor size and mitotic index were associated with free survival. The 3-year survival rate for patients with tumor size≤10 cm and>10 cm were 62.3% and 41.8%, respectively (P = 0.002), Tumors with mitotic index≤5/50 HPF had a higher 3-year survival rate than tumors with mitotic index>5/50 HPF (67.1% versus 40.7%, P = 0.005). The presence of necrosis was directly related to the malignant behavior. The 3-year survival rate for presence and absence necrosis were 50.8% and 64.8% (P = 0.008). From the present study, we can conclude that besides tumors size and mitotic index, tumor location and necrosis also influence on the long-term survival of patient with malignant GISTs after surgical resection.
LIANG Yumei, LI Xianghong, LU Youyong, LV Yali, ZHONG Mei, PU Xiaolu, LI Wenmei
《医学前沿(英文)》 2008年 第2卷 第1期 页码 87-94 doi: 10.1007/s11684-008-0016-z
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《医学前沿(英文)》 2017年 第11卷 第1期 页码 20-31 doi: 10.1007/s11684-016-0493-4
To date, gastric carcinoma (GC) is one of the common and fatal digestive malignancies worldwide. The prognosis of GC is not always satisfactory because of late diagnosis. Scholars are keen on discovering novel accurate and economical biomarkers in body liquids for GC screening to detect and evaluate the lesion before the results of imaging techniques are obtained. While traditional serum assays have limited sensitivity and specificity, gastrointestinal juice may provide relevant specific biomarkers because of its close contact with the tumor. Herein, the current progress in the relationship between gastrointestinal fluid analyses and GC is systematically and comprehensively reviewed. The detection of gastric juice pH, fluorescence spectrum, cytology, Helicobacter pylori-associated markers, nitrosamines, conventional tumor markers, amino acids, proteomics, microRNAs, long noncoding RNAs, protein-coding genes, vitamin C, etc., and combination tests of different category markers could provide important diagnostic and prognostic clues for gastrointestinal diseases. Particularly, early GC may be efficiently screened using gastric juice. Gastrointestinal fluid examination could also predict the adverse effects of postgastrectomy, such as pancreatic leakage, fistula, and abscess. Gastric fluid markers should be further studied to reveal the early predicators of malignancy and complications. The methods for obtaining the samples of gastrointestinal juice with minimum incision should also be comprehensively investigated.
关键词: gastrointestinal fluid gastric carcinoma biomarker diagnosis prognosis gastrectomy adverse events
《化学科学与工程前沿(英文)》 2022年 第16卷 第1期 页码 112-120 doi: 10.1007/s11705-021-2075-5
关键词: fluorescent drug lysosomal anticancer zebrafish nude-mouse tumour imaging
Immunotherapy-based combination strategies for treatment of gastrointestinal cancers: current status
Chenfei Zhou, Jun Zhang
《医学前沿(英文)》 2019年 第13卷 第1期 页码 12-23 doi: 10.1007/s11684-019-0685-9
Strategies in comprehensive therapy for gastrointestinal (GI) cancer have been optimized in the last decades to improve patients’ outcomes. However, treatment options remain limited for late-stage or refractory diseases. The efficacy of immune checkpoint inhibitors (ICIs) for treatment of refractory GI cancer has been confirmed by randomized clinical trials. In 2017, pembrolizumab was approved by the US Food and Drug Administration as the first agent for treatment of metastatic solid tumors with mismatch repair deficiency, especially for colorectal cancer. Given the different mechanisms, oncologists have focused on determining whether ICIs-based combination strategies could achieve higher efficacy than conventional therapy alone in late-stage or even front-line treatment of GI cancer. This review discusses the current status of combining immune checkpoint inhibitors with molecular targeted therapy, chemotherapy, or radiotherapy in GI cancer in terms of mechanisms, safety, and efficacy to provide basis for future research.
关键词: gastrointestinal cancer immune checkpoint inhibitor combination therapy
Gastrointestinal damage caused by swallowing multiple magnets
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《医学前沿(英文)》 2012年 第6卷 第3期 页码 280-287 doi: 10.1007/s11684-012-0207-5
Swallowing multiple magnets is not uncommon worldwide and it frequently leads to serious consequences. However, most patients fail to receive timely and correct diagnosis and treatment. A literature search was performed to establish an algorithm for these accidents by the authors to identify relevant articles published from June 1987 to October 2010 in Google, Medline, ISI Web of Knowledge Ovid, CNKI, Korea Med and library document delivery, using search terms “magnet ingestion, ” “fistula, ” and “perforation. ” A total of 149 patients with ingestion of magnetic foreign bodies from 20 countries and areas were identified. 22 of them were companioned with neurological and psychiatric disorders. Swallowing magnets occurred throughout childhood and adolescent, mostly ranging 2 to 4 years in age. Various gastrointestinal damages such as necrosis and intestinal perforation or fistula were encountered. Damage from swallowing multiple magnets carries a significant risk of morbidity and even mortality throughout childhood to adolescent worldwide. Older children and adults with neurological and psychiatric problems may be at high risk for such accidents. Early intervention is crucial.
Detecting genetic hypermutability of gastrointestinal tumor by using a forensic STR kit
Anqi Chen, Suhua Zhang, Jixi Li, Chaoneng Ji, Jinzhong Chen, Chengtao Li
《医学前沿(英文)》 2020年 第14卷 第1期 页码 101-111 doi: 10.1007/s11684-019-0698-4
关键词: mismatch repair protein deficiency (MMR-D) microsatellite instability (MSI) short tandem repeats (STR) gastrointestinal tumor hypermutability
Histone variants: critical determinants in tumour heterogeneity
Tao Wang, Florent Chuffart, Ekaterina Bourova-Flin, Jin Wang, Jianqing Mi, Sophie Rousseaux, Saadi Khochbin
《医学前沿(英文)》 2019年 第13卷 第3期 页码 289-297 doi: 10.1007/s11684-018-0667-3
Ingestible wireless capsules for enhanced diagnostic inspection of gastrointestinal tract
Mahdi RASOULI, Andy Prima KENCANA, Van An HUYNH, Eng Kiat TING, Joshua Chong Yue LAI, Kai Juan WONG, Su Lim TAN, Soo Jay PHEE
《机械工程前沿(英文)》 2011年 第6卷 第1期 页码 40-44 doi: 10.1007/s11465-011-0204-4
Wireless capsule endoscopy has become a common procedure for diagnostic inspection of gastrointestinal tract. This method offers a less-invasive alternative to traditional endoscopy by eliminating uncomfortable procedures of the traditional endoscopy. Moreover, it provides the opportunity for exploring inaccessible areas of the small intestine. Current capsule endoscopes, however, move by peristalsis and are not capable of detailed and on-demand inspection of desired locations. Here, we propose and develop two wireless endoscopes with maneuverable vision systems to enhance diagnosis of gastrointestinal disorders. The vision systems in these capsules are equipped with mechanical actuators to adjust the position of the camera. This may help to cover larger areas of the digestive tract and investigate desired locations. The preliminary experimental results showed that the developed platform could successfully communicate with the external control unit via human body and adjust the position of camera to limited degrees.
关键词: wireless capsule endoscopy ingestible medical device in-body medical device miniature actuator medical robot medical imaging
Artificial intelligence in gastroenterology: where are we heading?
Joseph JY Sung, Nicholas CH Poon
《医学前沿(英文)》 2020年 第14卷 第4期 页码 511-517 doi: 10.1007/s11684-020-0742-4
关键词: artificial intelligence endoscopy robotics gastrointestinal diseases
血清免疫球蛋白G N-糖基的高通量分析——一种消化道癌症的非侵入性生物标志物 Article
刘鹏程, 王小兵, 顿爱社, 李昱潼, 李厚强, 王璐, 张怡春, 李灿灿, 张金霞, 张晓雨, 马立兴, 侯海峰
《工程(英文)》 2023年 第26卷 第7期 页码 44-53 doi: 10.1016/j.eng.2023.02.008
免疫球蛋白G (Immunoglobulin G, IgG) 的 N-糖基化在炎症性疾病的发展中起着重要作用。本研究旨在评价IgG N-糖基在消化道癌症亚型中的诊断效能。从中国医学科学院肿瘤医院招募749名消化道癌症患者,包括食管癌 (esophageal cancer, EC)、胃癌 (gastric cancer, GC)、结直肠癌 (colorectal cancer, CRC) 和胰腺癌 (pancreatic cancer, PC) 患者。采用亲水交互高效液相色谱-超高效液相色谱(hydrophilic interaction liquid chromatography using ultra-performance liquid chromatography, HILIC-UPLC)分析血浆中IgG的 N-糖基构成。采用Bio-Plex悬液芯片系统检测方法(Bio-Rad)进行炎症因子检测。采用典型相关分析(canonical correlation analysis, CCA)探索糖基和炎症因子之间的相关性。 采用LASSO回归和logistic回归模型,基于检测到的糖基谱建立可用于区分胃肠癌症患者和健康人群诊断模型。与健康对照组相比,EC、GC、CRC和PC患者的唾液酸化和半乳糖基化水平降低,而二等分乙酰葡萄糖胺基化水平在消化道癌症患者中升高。 此外,只有胰腺癌患者具有低水平的岩藻糖基化。消化道癌症组的IL-1β、IL-31和sCD40L水平均高于对照组。IgG N-糖基的组成与炎症因子相关 (r = 0.556)。基于糖基的模型表现出良好的诊断效能,EC、GC、CRC和PC的受试者工作特征曲线下面积(AUC)分别为0.972、0.871、0.867和0.907。这些研究结果表明,IgG N-糖基在调节消化道肿瘤的发病机制中发挥了重要作用。血清IgG N-糖基可以作为潜在的非侵入性辅助消化道癌症临床诊断的方法。
Endoscopic resection of a huge Brunner's gland adenoma
ZHANG Binbin, REN Xu, TANG Xiufen, CHI Yuxin, SHI Xuesong
《医学前沿(英文)》 2008年 第2卷 第4期 页码 414-418 doi: 10.1007/s11684-008-0080-4
关键词: superior Histological examination endoscopy gastro-intestinal gastrointestinal haemorrhage
Marc Mac Giolla Eain, Joanna Baginska, Kacy Greenhalgh, Joëlle V. Fritz, Frederic Zenhausern, Paul Wilmes
《工程(英文)》 2017年 第3卷 第1期 页码 60-65 doi: 10.1016/J.ENG.2017.01.011
研究宿主–胃肠道微生物的相互作用已经成为管理人类健康和疾病的关键组成部分。微生理系统的发展正在为研究人员提供前所未有的对于这种复杂关系的获取和理解。这些系统结合了微型工程、微流体和细胞培养的优点,来创建人类肠道中普遍存在的环境条件。在这里我们提出的HuMiX(人类微生物交联对话) 平台,是一个利用这种多学科方法提供具有代表性的人体胃肠道的体外模型系统,用于研究宿主–微生物分子的相互作用。我们总结了使用该平台获得的概念验证结果,强调其对于大大增强我们对宿主–微生物相互作用了解的潜力,且其可能对药物、食品和营养以及医疗保健行业产生的巨大影响。同时讨论了这些技术面临的一些关键问题和挑战。
标题 作者 时间 类型 操作
Potential indicators predict progress after surgical resection of gastrointestinal stromal tumors
null
期刊论文
Prognostic significance of clinicopathologic parameters in gastrointestinal stromal tumors: a study of
LIANG Yumei, LI Xianghong, LU Youyong, LV Yali, ZHONG Mei, PU Xiaolu, LI Wenmei
期刊论文
Detection of digestive malignancies and post-gastrectomy complications via gastrointestinal fluid examination
null
期刊论文
Novel lysosome-targeted anticancer fluorescent agents used in zebrafish and nude mouse tumour imaging
期刊论文
Immunotherapy-based combination strategies for treatment of gastrointestinal cancers: current status
Chenfei Zhou, Jun Zhang
期刊论文
Detecting genetic hypermutability of gastrointestinal tumor by using a forensic STR kit
Anqi Chen, Suhua Zhang, Jixi Li, Chaoneng Ji, Jinzhong Chen, Chengtao Li
期刊论文
Histone variants: critical determinants in tumour heterogeneity
Tao Wang, Florent Chuffart, Ekaterina Bourova-Flin, Jin Wang, Jianqing Mi, Sophie Rousseaux, Saadi Khochbin
期刊论文
Ingestible wireless capsules for enhanced diagnostic inspection of gastrointestinal tract
Mahdi RASOULI, Andy Prima KENCANA, Van An HUYNH, Eng Kiat TING, Joshua Chong Yue LAI, Kai Juan WONG, Su Lim TAN, Soo Jay PHEE
期刊论文
Artificial intelligence in gastroenterology: where are we heading?
Joseph JY Sung, Nicholas CH Poon
期刊论文
血清免疫球蛋白G N-糖基的高通量分析——一种消化道癌症的非侵入性生物标志物
刘鹏程, 王小兵, 顿爱社, 李昱潼, 李厚强, 王璐, 张怡春, 李灿灿, 张金霞, 张晓雨, 马立兴, 侯海峰
期刊论文
Endoscopic resection of a huge Brunner's gland adenoma
ZHANG Binbin, REN Xu, TANG Xiufen, CHI Yuxin, SHI Xuesong
期刊论文